Dually degradable click hydrogels for controlled degradation and protein release

Dually degradable click hydrogels for controlled degradation and protein release.

Temperature-responsive and degradable hyaluronic acid/Pluronic composite hydrogels for controlled release of human growth hormone.

Temperature-sensitive hyaluronic acid (HA) hydrogels were synthesized by photopolymerization of vinyl group modified HA in combination with acrylate group end-capped poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer (Pluronic F127). The synthesized HA/Pluronic composite hydrogels gradually collapsed with increasing temperature over the range of 5-40 degrees ...

numerical analysis of temperature-sensitive hydrogels for controlled drug release

today hydrogels are considered as the materials that are able to play important role in drug delivery systems. to design an effective hydrogel applicable network, mathematical modeling has a critical role. a successful drug delivery device relies not only on intelligent network design but also on accurate prior mathematical modeling of drug release profiles. in this study, the modeling of the i...

Antimicrobial Modified-Tragacanth Gum/Acrylic Acid Hydrogels for the Controlled Release of Quercetin

In this study, new antimicrobial hydrogels were prepared via reaction of functionalized-tragacanthgum (TG) biopolymer by quaternary ammonium functionalization of TG (QTG) with acrylic acid(AA). Characterization of the QTG hydrogels (QTG-AA) was carried out by FTIR,thermogravimetric analysis (TGA), and 1H NMR. Dynamic mechanical analysis, (DMA) wasconducted to characteriz...

Hydrolytically degradable hyaluronic acid hydrogels with controlled temporal structures.

Polysaccharides are being processed into biomaterials for numerous biological applications due to their native source in numerous tissues and biological functions. For instance, hyaluronic acid (HA) is found abundantly in the body, interacts with cells through surface receptors, and can regulate cellular behavior (e.g., proliferation, migration). HA was previously modified with reactive groups ...